![]() ![]() People with addisonian crisis have a more serious illness that is a medical emergency. Darkening of the skin over knuckles, knees, elbows, toes, or lips, creases of palms, and mucous membranes may be present. Others may feel weak, tired, or sick to the stomach there may also be weight loss, decreased appetite, low blood pressure, depression, or skin and hair changes. What Are the Symptoms of Addison’s Disease? Surgery, medicines with harmful side effects, and x-ray treatments can also cause the disorder. Adrenal glands may also develop poorly from birth. Other causes include infections (e.g., tuberculosis, AIDS), cancer, bleeding, and blocked blood vessels involving the adrenal glands. In an autoimmune disease, the body makes substances (antibodies) that damage adrenal glands. What Causes Addison’s Disease?Īddison’s disease develops because the immune system (disease-fighting system) doesn’t work well. There is no effective way to prevent Addison’s disease. Also, potassium builds up to a dangerous level. Without these hormones, salt and water in the body is lost in urine, which makes blood pressure fall too low. ![]() ![]() They usually produce hormones called cortisol and aldosterone. The two small adrenal glands sit atop the kidneys. Addison’s disease, also known as adrenal insufficiency, is a condition in which the adrenal glands don’t work well.
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